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PAUSE AND PONDER: On average, how long do you think a patient can remain adherent to the ketogenic diet lifestyle

Its impact on inactivation of mitochondrial proteins depends on the level of generation in mitochondria

167,168 In hepatocytes, elevated lipid load and insulin resistance increase mitochondrial -oxidation activity, accompanied by electron leakage and respiratory chain disruption, resulting in substantial ROS production, which exacerbates lipid peroxidation, autophagic dysfunction, and pyroptosis

Br J Clin Pharmacol 34:7981 Mitchell SJ, Hilmer SN, Murnion BP, Matthews S (2011) Hepatotoxicity of therapeutic short-course paracetamol in hospital inpatients: impact of ageing and frailty